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  • Title: Specific overexpression of P53 in sarcoma derived from Rat-1 cells transformed by cigarette smoking condensate-treated human fetal lung DNA.
    Author: Li ZQ, Wei HJ, Luo XM, Liu XY, Chen ZG, Dai JW, Feng YM.
    Journal: J Environ Pathol Toxicol Oncol; 1994; 13(3):187-90. PubMed ID: 7722886.
    Abstract:
    The p53 protein is highly expressed in fibrosarcoma derived from Rat-1 cells transfected with cigarette smoke condensate-treated human fetal lung DNA but expressed low in the counterparts of nitroso-N-methylurea and dimethyl sulfoxide groups. Our results denoted that a high expression of p53 protein specifically contributes to the initiation of human lung carcinogenesis induced by cigarette smoke condensate. High expression and missense mutation of p53 may probably be a potential biomarker of initiation of human lung carcinogenesis.
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