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  • Title: The nucleotide sequence and initial characterization of pyruvate decarboxylase from the yeast Hanseniaspora uvarum.
    Author: Holloway P, Subden RE.
    Journal: Yeast; 1994 Dec; 10(12):1581-9. PubMed ID: 7725793.
    Abstract:
    We have isolated a pyruvate decarboxylase (PDC) gene from the yeast Hanseniaspora uvarum using the Saccharomyces cerevisiae PDC1 gene as a probe. The nucleotide sequence of this gene was determined and compared to PDC genes from yeast and other organisms. The H. uvarum PDC gene is more than 70% identical to the S. cerevisiae PDC isozymes and possesses a putative thiamine diphosphate binding site. The PDC enzyme was purified and partially characterized. The H. uvarum PDC was very similar to other known PDCs; the Km for pyruvate was 0.75 mM, and the enzyme is a homotetramer with subunits of M(r) = 57,000.
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