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  • Title: DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.
    Author: Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y.
    Journal: Antimicrob Agents Chemother; 1995 Feb; 39(2):561-3. PubMed ID: 7726535.
    Abstract:
    Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.
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