These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.
    Author: Chapman JS, Bertasso A, Cummings LM, Georgopapadakou NH.
    Journal: Antimicrob Agents Chemother; 1995 Feb; 39(2):564-6. PubMed ID: 7726536.
    Abstract:
    Four spontaneous, single-step mutants of Escherichia coli K-12 resistant to low levels of the cephalosporin 3'-quinolone ester Ro 23-9424 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resistant to fleroxacin. There was no increase in beta-lactamase activity when tested with nitrocephin, and the penicillin-binding protein profiles were normal.
    [Abstract] [Full Text] [Related] [New Search]