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  • Title: Genotoxic risk assessment of drinking water consumed in the city of Tehran, Iran.
    Author: Sabouni F, Zia'ee AA.
    Journal: Arch Environ Contam Toxicol; 1995 Apr; 28(3):391-5. PubMed ID: 7726647.
    Abstract:
    Two hundred liters of drinking water of the city of Tehran were collected as tap water in a glass container and passed through a XAD-2 resin column at a flow rate of 60-100 ml/minute. The adsorbed materials were eluted with acetone, dried and dissolved in 2 ml dimethylsulfoxide (DMSO). Doses up to 10 microliters did not elevate sister chromatid exchanges (SCE) in CHO fibroblasts, while 20 microliters caused a significant increase in SCE. However, this dose did not show any chromosomal aberration (CA) in V79 fibroblasts. Doses up to 50 microliters of the extract did not increase his+ spontaneous revertant colonies in Salmonella typhimurium tester strain TA98, TA100 and TA102 in the absence of S9 metabolizing mixture, neither induced DNA alkaline labile sites in V79 fibroblasts.
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