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  • Title: Endothelin concentrations in experimental sepsis: profiles of big endothelin and endothelin 1-21 in lethal peritonitis in rats.
    Author: Lundblad R, Giercksky KE.
    Journal: Eur J Surg; 1995 Jan; 161(1):9-16. PubMed ID: 7727611.
    Abstract:
    OBJECTIVE: To define the profiles of endothelin (ET), both big ET and active 21 amino acid ET (ET 1-21) in the plasma and peritoneal cavity of rats with peritonitis. DESIGN: Open laboratory study. SETTING: University hospital, Norway. MATERIAL: 170 adult male Wistar rats. INTERVENTIONS: Lethal peritonitis was induced by making a 4 mm caecal perforation. MAIN OUTCOME MEASURES: Mortality, together with concentrations of total ET, ET 1-21 (measured by two radioimmunoassays), bacteria, endotoxin, tumor necrosis factor (TNF), interleukin 6 (IL-6), and lactate at baseline, two hours, and then four-hourly intervals for 24 hours. RESULTS: ET reached its maximum at 8 hours, and had returned to baseline after 24 hours. In the first phase of septicaemia there was more big ET than ET 1-21, but the proportions had equalised by 8 hours. There were higher concentrations of both big ET and ET 1-21 in peritoneal fluid than in plasma. CONCLUSIONS: In rats with peritonitis the profiles of big ET and ET 1-21 closely followed mortality, and blood concentrations of bacteria, endotoxin, TNF, IL-6, and lactate.
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