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  • Title: Quality-of-life results of double-blind, placebo-controlled trial of mesalamine in patients with Crohn's disease.
    Author: Singleton JW, Hanauer S, Robinson M.
    Journal: Dig Dis Sci; 1995 May; 40(5):931-5. PubMed ID: 7729281.
    Abstract:
    Seven quality-of-life parameters were assessed in a trial of mesalamine in Crohn's disease. The results with regard to efficacy and safety have been previously published. A total of 310 patients were enrolled in this double-blind, parallel trial and randomized to receive placebo, or 1, 2, or 4 g/day of mesalamine in controlled-release capsules for 16 weeks. Results revealed that mesalamine at the dose of 4 g/day resulted in significant (P < 0.03) improvements from baseline in all quality-of-life parameters. A significant (P < 0.02) linear trend between increasing doses of mesalamine and increasing response was also noted. The 1- and 2-g/day doses of mesalamine also resulted in an improvement in quality of life, however, with the exception of 2 g/day of mesalamine on the hobby and recreational activities parameter, these changes were not significantly different from placebo.
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