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  • Title: New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186.
    Author: Yamada H, Shiomi K, Xu Q, Nagai T, Shibata M, Oya I, Takahashi Y, Omura S.
    Journal: J Antibiot (Tokyo); 1995 Mar; 48(3):205-10. PubMed ID: 7730153.
    Abstract:
    New panosialin analog, panosialins D and wD have been isolated from the culture broth of Streptomyces sp. OH-5186. Their structures were elucidated as 5-(13-methylpentadecyl)-1,3-benzenediol bis(sodium sulfate) and 5-(13-methylpentadecyl)-1,3-benzenediol 1-(sodium sulfate), respectively. They showed strong inhibitory activity against alpha-mannosidase, alpha-glucosidase, and beta-glucosidase. Panosialins wA-wD mixture also showed weak mitogenic activity but suppressed the mitogen induced activity.
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