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  • Title: [Interferon production in peripheral blood cells of patients with pulmonary mycobacterial disease].
    Author: Tada A, Kawahara S, Tamaoki A, Takeuchi M, Tanimoto Y, Okada C, Mishima Y, Soda R, Takahashi K, Kibata M.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1995 Feb; 33(2):114-9. PubMed ID: 7731113.
    Abstract:
    Production of interferon (IFN)-alpha and IFN-gamma were examined in 31 patients with acute tuberculosis, 12 patients with atypical mycobacterial disease. IFN production was examined in cultures of unseparated fresh whole blood. Production of IFN-alpha was induced by hemagglutinating virus of Japan and production of IFN-gamma was induced by PHA. Patients with mycobacterial disease produced significantly less IFN-alpha than healthy subjects. In patients with acute tuberculosis, effective chemotherapy for 2 months restored IFN-alpha production. Patients produced less IFN-gamma than healthy subjects, but the difference was not significant. Patients with high serum CRP levels tended to produce little IFN-alpha. These results suggest that measurement of IFN production is useful for immunological evaluation of patients with mycobacterial disease.
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