These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Anti-beta 2 glycoprotein I antibodies. Relationship with antiphospholipid antibodies and thrombosis].
    Author: Ordi Ros J, Falgà Tirado C, Monegal Ferran F, Selva O'Callaghan A, Pérez Pemán P, Cucurull E, Vilardell Tarres M.
    Journal: Med Clin (Barc); 1995 Feb 25; 104(7):245-8. PubMed ID: 7731286.
    Abstract:
    BACKGROUND: Anti-beta 2-glycoprotein I antibodies (a beta 2GPI) were studied in patients with diseases or clinical symptoms related to antiphospholipid antibodies (aPl) with the aim of establishing a relationship between both antibodies and these clinical manifestations. METHODS: The a beta 2GPI antibodies were determined by enzymeimmunoassay in a group of 94 altruist blood donors and 135 patients (98 with systemic lupus erythematosus, 21 cases of primary antiphospholipid syndrome, 10 cases with idiopathic Sneddon syndrome and 6 with Q fever). The lupus anticoagulating-type aPl antibodies were determined in the same subjects by kaolin coagulation time and the Russell's viper venom time while anticardiolipin-type IgG, IgM and IgA isotypes were determined by enzymeimmunoassay. The a beta 2GPI antibodies were related with the aPl antibodies, fetal losses and history of thrombosis by a contingency table with Yates correction in the first two parameters and means comparison by the Students' t test for the history of thrombosis. RESULTS: The aPl and a beta 2GPI antibodies in the control group were negative. In the group of patients the latter antibodies were positive in 33.6% (33 cases) of the patients with lupus, 57% (12 cases) of the patients with primary antiphospholipid syndrome, in one of the patients with the Sneddon syndrome and in none of the patients with Q fever. The aPl antibodies were positive in 26.5% of the patients with lupus and in 100% of the cases with primary antiphospholipid syndrome or Q fever and negative in all the cases with idiopathic Sneddon syndrome. A significant relationship was found between the a beta 2GPI antibodies and thrombotic manifestations (p = 0.01) or obstetric complications (p < 0.04). A dependent relationship was observed in both autoantibodies (aPl and a beta 2GPI) (p < 0.01). CONCLUSIONS: There is a significant relationship between the antiphospholipid antibodies and the anti-beta 2-glycoprotein I antibodies in addition to a relationship with thrombotic symptoms or obstetric complications.
    [Abstract] [Full Text] [Related] [New Search]