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  • Title: Peptide mimicry of the meningococcal group C capsular polysaccharide.
    Author: Westerink MA, Giardina PC, Apicella MA, Kieber-Emmons T.
    Journal: Proc Natl Acad Sci U S A; 1995 Apr 25; 92(9):4021-5. PubMed ID: 7732025.
    Abstract:
    Sequence analysis of the variable regions of the heavy and light chains of the anti-idiotypic antibody 6F9, which mimics the meningococcal group C capsular polysaccharide (MCP), was performed. The immunogenic site on 6F9 responsible for inducing an anti-MCP antibody response was determined by means of sequence and computer model analysis of these data. Complementarity-determining region 3 (CDR3) was found to be unique in that the sequence tract YRY was exposed on the surface. A synthetic peptide spanning the CDR3 domain was synthesized and complexed to proteosomes (meningococcal group B outer membrane protein). Immunizations of BALB/c mice with the peptide-proteosome complex resulted in a significant anti-MCP antibody response. Immunized mice were protected against infection with a lethal dose of Neisseria meningitidis serogroup C.
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