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  • Title: [Effect of aflatoxin B1 on monooxygenase activity in liver microsomes exposed to cytochrome P-450].
    Author: Astashkin EI, Prikhodko AZ.
    Journal: Vopr Pitan; 1994; (6):6-8. PubMed ID: 7732678.
    Abstract:
    Effect of aflatoxin B1 (AFB1) on microsomal ethoxycumarindeethylase (ECDE) and amidopyrindemethylase (APDM) activities in liver of Wistar rats treated with inductors of different forms of cytochrome P-450 (P-450) 3-methylcholanthrene (3-MC) and phenobarbital (PB) were studied. AFB1 caused strong inhibition of ECDE activity, induced by 3-MC. 150 for AFB1 was equal 3.2 10-5. In the same time AFB1 did not effect on basal and PB induced ECDE and APDM activities. Participation of MC induced forms of cytochrome P-450 (P-448) in activation of AFB1 is supposed.
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