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  • Title: [Characteristics of the interaction of the A-factor with mutant 1439 of Act. streptomycini in the biosynthesis of streptomycin].
    Author: Kornitskaia EIa, Tovarova II, Khokhlov AS.
    Journal: Antibiotiki; 1975 Nov; 20(11):978-82. PubMed ID: 773281.
    Abstract:
    Some peculiar properties of A-factor using by mutant 1439 of Act. streptomycini were studied. It was found that A-factor was most intensively used for biosynthesis of streptomycin when it was added during inoculation. When A-factor was added to a I- or 2-day culture it was required in 10 times higher amounts and its high non-specific adsorption by the mycelium was observed. Interaction of A-factor with the mycelium providing restoration of the biosynthetic process was very rapid on a short-term contat of the I-day culture with A-factor. Transformations occurring under the effect of A-factor and leading to formation of streptomycin took place mainly inside the cells. Changes in the life cycle induced by A-factor developed under different conditions as compared to those promoting streptomycin biosynthesis.
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