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  • Title: Endothelin regulates PGE2 formation in rat mesangial cells through induction of prostaglandin endoperoxide synthase-2.
    Author: Coroneos E, Kester M, Thomas P, Dunn MJ.
    Journal: Adv Prostaglandin Thromboxane Leukot Res; 1995; 23():117-9. PubMed ID: 7732815.
    Abstract:
    Endothelin-1 stimulates vascular smooth muscle and mesangial cells to release prostaglandin E2 which attenuates the vasoconstrictor and mitogenic effects of endothelin. The role of endothelin-1 to regulate prostaglandin endoperoxide synthase (PGHS)-1 and -2 gene expression and protein synthesis was evaluated in cultured mesangial cells. Endothelin induced mRNA and protein expression for PGHS-2 but not for PGHS-1. A direct correlation was observed between the mass of immunoprecipitated PGHS protein and PGE2 synthetic enzymatic activity.
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