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  • Title: Palladium--a new inhibitor of cellulase activities.
    Author: Shultz MD, Lassig JP, Gooch MG, Evans BR, Woodward J.
    Journal: Biochem Biophys Res Commun; 1995 Apr 26; 209(3):1046-52. PubMed ID: 7733957.
    Abstract:
    Palladium complexes have been shown to strongly inhibit cellobiohydrolase I (CBH I) and endoglucanase II (EG II), two cellulases produced by Trichoderma reesei. Also inhibited were total cellulase (Avicelase) and beta-glucosidase (cellobiase) activities. The catalytic domain of CBH II, the second most abundant component of this cellulase, appeared less susceptible to inhibition by palladium. The inhibition was irreversible and could be prevented if histidine, cysteine or cystine was added to the enzyme reaction mixture simultaneously with the inhibitor. The binding of CBH I to microcrystalline cellulose (Avicel) was unaffected by palladium.
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