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  • Title: [Pharmacokinetic characteristics of a massive dose of furosemide in acute kidney failure].
    Author: Lucas A, Meignan M, Le Gall JR, Tillement JP, Rapin M.
    Journal: Biomedicine; 1976 Jan; 24(1):45-9. PubMed ID: 773444.
    Abstract:
    A pharmacokinetic study with high doses of frusemide has been performed in nine patients with acute tubulopathy, treated by hemodialysis. The patients were studied between 6 and 28 days after the beginning of the disease. Renal function was normal before the episode of acute renal shutdown. The diuretic effect of frusemide was closely related to creatinine clearance (Ccr): no effect in anuric cases, moderate effect if Ccr was lower than 10 ml/mn, marked effect if Ccr was higher than 10 ml/mn. no direct relationship could be demonstrated between drug plasma level and natriuresis. Frusemide half-life in plasma was short even in anuric patients, suggesting the existence of an extra renal excretion and/or inactivation pathway. Hence toxic side effects due to drug accumulation should not appear in the recommended 1 g/day regimen.
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