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  • Title: Determination of oxeladin in human plasma by gas chromatography--mass spectrometry.
    Author: Lartigue-Mattei C, Galmier MJ, Chabard JL, Beyssac E, Aiache JM.
    Journal: Biomed Chromatogr; 1995; 9(1):32-5. PubMed ID: 7734931.
    Abstract:
    A capillary gas chromatographic method with mass-selective detection was developed for the determination of oxeladin in human plasma. Plasma samples (1 mL) were alkalinized and extracted using 5mL of hexane: isoamyl alcohol (99:1). The method was demonstrated to be sensitive (limit of quantitation at 1 ng/mL), linear between 1 and 150 mg/mL, accurate and precise enough (mean error and mean coefficient of variation at the limit of quantitation were 2.3 and 13.3%, respectively) to support pharmacokinetic evaluation of the drug at doses down to 30 mg.
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