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  • Title: Determination of piracetam in human plasma and urine by liquid chromatography.
    Author: Louchahi K, Tod M, Bonnardel P, Petitjean O.
    Journal: J Chromatogr B Biomed Appl; 1995 Jan 20; 663(2):385-9. PubMed ID: 7735487.
    Abstract:
    A method for the determination of piracetam in human plasma and urine by liquid chromatography with absorbance detection at 206 nm and isocratic elution is proposed. The assay involved a liquid-liquid extraction into hexane-2-propanol at pH 9.2. The calibration graphs were linear in the range 3-40 mg/l in plasma and 100-2000 mg/l in urine. Bias was negligible and coefficients of variation were less than 10% throughout the working range except at 100 mg/l in urine. The limits of quantification were 3 mg/l in plasma and 100 mg/l in urine. The assay was reliably used for pharmacokinetic studies in humans after administration of 800 mg of piracetam per os.
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