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  • Title: Effects of inhibitors of cGMP-dependent protein kinase in atrial heart and aortic smooth muscle from rats.
    Author: Bäumner D, Nawrath H.
    Journal: Eur J Pharmacol; 1995 Feb 06; 273(3):295-8. PubMed ID: 7737337.
    Abstract:
    Several activators of cGMP-dependent protein kinase (protein kinase G) such as 8-Br-cGMP reduced force of contraction in rat left atria. Inhibitors of protein kinase G antagonized the negative inotropic effect of 8-Br-cGMP but not of acetylcholine in atria. However, the acetylcholine-induced relaxation in aortic rings was significantly inhibited by protein kinase G inhibition. It is concluded that the reduction by 8-Br-cGMP of force of contraction in atria is related to activation of protein kinase G. In response to acetylcholine, activation of protein kinase G is probably a major step in smooth muscle relaxation but is not involved in the reduction of force of contraction in atria.
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