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  • Title: Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons.
    Author: Molnár P, Erdö SL.
    Journal: Eur J Pharmacol; 1995 Feb 06; 273(3):303-6. PubMed ID: 7737339.
    Abstract:
    The effects of vinpocetine and phenytoin on voltage-gated Na+ channels were examined on cultured cerebrocortical neurones of the rat using a conventional whole-cell patch-clamp method. Vinpocetine and phenytoin decreased Na+ currents in a concentration-dependent manner, with IC50 values of 44.2 +/- 14.6 and 50.5 +/- 17.4 microM, respectively. Both compounds shifted the voltage dependence of the steady-state inactivation of the channel in the hyperpolarising direction. This pronounced Na+ channel blocking activity may contribute to the neuroprotective and anticonvulsant effects of vinpocetine.
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