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  • Title: Effect of the kinase inhibitor 2-aminopurine on the cell cycle stage-dependent phosphorylation state of the retinoblastoma protein.
    Author: Metheny LJ, Nelson DA, Ludlow JW.
    Journal: Exp Cell Res; 1995 May; 218(1):151-4. PubMed ID: 7737355.
    Abstract:
    We investigated the effect of 2-aminopurine (2-AP) on the cell cycle stage-dependent phosphorylation state of the retinoblastoma growth suppressor protein (pRB). Our results suggest that 2-AP does not affect dephosphorylation of pRB scheduled during metaphase/anaphase of mitosis, even though 2-AP-treated cells never enter metaphase or anaphase. Phosphorylation of pRB, which is important for G1 exit, appeared to be impeded by 2-AP late during G1, coincident with a slowing of G1 cell progression into S phase. The significance of these data with regard to cell cycle regulation is discussed.
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