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  • Title: Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.
    Author: Joseph-Horne T, Manning NJ, Hollomon D, Kelly SL.
    Journal: FEMS Microbiol Lett; 1995 Mar 15; 127(1-2):29-34. PubMed ID: 7737481.
    Abstract:
    Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol delta 5(6)desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta,6 alpha-diol and an increase in the proportion of 14 alpha-methylfecosterol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.
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