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  • Title: Synthesis, physico-chemical and biological properties of some alkali metals and quaternary alkylammonium salts of polyene antibiotics: amphotericin B, nystatin and aureofungin.
    Author: Chatterjee NR, Badave VM, Pawar DA.
    Journal: Hindustan Antibiot Bull; 1994; 36(1-2):34-8. PubMed ID: 7737895.
    Abstract:
    Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.
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