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  • Title: Transplantation of autologous tissue fragments into an e-PTFE graft with long fibrils.
    Author: Noishiki Y, Yamane Y, Tomizawa Y, Matsumoto A.
    Journal: Artif Organs; 1995 Jan; 19(1):17-26. PubMed ID: 7741633.
    Abstract:
    An expanded polytetrafluoroethylene (e-PTFE) graft with long fibrils transplanted with bone marrow showed rapid and uniform neointima formation in a dog study. The e-PTFE grafts (fibril length, 90 microns; 6 mm internal diameter; length, 6-8 cm) transplanted with autologous bone marrow were implanted in the abdominal aortae of 10 dogs and retrieved at 3 weeks and 3 months after implantation. Control e-PTFE grafts without bone marrow treatment were also implanted in the same manner in 8 dogs. Macroscopically the treated graft wall appeared red in color; however, there was no thrombus deposition on the surface. Light microscopic observation revealed that the treated grafts were completely lined with endothelial cells at 3 weeks. The neointima was uniform without intimal hyperplasia at the anastomotic sites. Inside the graft wall many capillary blood vessels were observed. At 3 months moderate intimal hyperplasia throughout the graft with complete endothelialization was observed. In the control grafts, endothelialization was observed at the anastomotic sites; however, half of the other areas were covered with a fibrin layer devoid of endothelial cells even in the 3-month grafts. These results indicated that neointima formation was effectively accelerated with the autologous bone marrow transplantation, but moderate intimal hyperplasia throughout the graft was inevitable in e-PTFE grafts even after complete endothelialization.
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