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  • Title: A high phosphotyrosine phosphatase activity is present in differentiating bovine lens cells.
    Author: Blanquet PR, Croquet F.
    Journal: Cell Biol Int; 1995 Feb; 19(2):121-8. PubMed ID: 7742776.
    Abstract:
    Activity of phosphotyrosine-protein phosphatases (PTPases) has been investigated in the different cellular regions of bovine eye lens. PTPases were tested in cellular detergent extracts using phospholabelled synthetic peptides and p-nitrophenyl phosphate. We show that a high PTPase activity is only present in cells which undergo differentiation, namely the equatorial epithelium and cortex fiber cells. Since this activity is found to be severely inhibited by a specific inhibitor of receptor-type PTPases, it can be suggested that one or more members of this class of PTPases might play an important role in the lens differentiation process.
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