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  • Title: A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
    Author: Faucheu C, Diu A, Chan AW, Blanchet AM, Miossec C, Hervé F, Collard-Dutilleul V, Gu Y, Aldape RA, Lippke JA.
    Journal: EMBO J; 1995 May 01; 14(9):1914-22. PubMed ID: 7743998.
    Abstract:
    We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3. A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published. This model suggests that TX is a cysteine protease, with the P1 aspartic acid substrate specificity retained. Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta. In addition, this protein induces apoptosis in transfected COS cells. TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death.
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