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  • Title: [An unusual case of subacute sclerosing panencephalitis].
    Author: Sela BA, Hassin-Baer S, Goldhamer Y, Polak-Charcon S, Nass D, Duvdevani P, Shulman L.
    Journal: Harefuah; 1995 Mar 01; 128(5):273-6, 336, 335. PubMed ID: 7744346.
    Abstract:
    A 25-year-old man was admitted following deterioration in behavior and onset of blindness. He soon became comatose and died 6 weeks later. Brain biopsy showed nuclear inclusion bodies resembling viral capsids, astrocytosis and perivascular lymphocytic cuffing but no demyelination. The diagnosis of subacute sclerosing panencephalitis was made on finding: measles virus antigens in both serum and cerebrospinal fluid, the identification of measles RNA sequences in brain tissue by the polymerase chain reaction, and intense, oligoclonal, IgG-banding in the CSF. However, the relatively advanced age of the patient, the absence of myoclonus and the nondistinctive EEG profile lacking synchronous bursts of high-voltage slow and sharp waves, are unusual.
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