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  • Title: Effect of hematocrit on dialyzer urea and creatinine clearance indices in a hemodialysis patient with erythrocytosis.
    Author: Nwosu AC, Tzamaloukas AH, Malhotra D, Saddler MC, Murata GH.
    Journal: Int J Artif Organs; 1994 Nov; 17(11):591-4. PubMed ID: 7744519.
    Abstract:
    The association between azotemic index dialyzer clearances and hematocrit was investigated in a 63-year-old dialysis-dependent man with acquired renal cysts. During 43 months of hemodialysis, hematocrit rose from 27.3 to 65.0 vol%, as a consequence of high serum erythropoietin levels. Concomitantly, dry weight also increased from 116.8 to 140.8 kg. Both hematocrit and dry weight correlated with: (a) urea reduction ratio, (b) creatinine reduction ratio (CRR), and (c) KT/V urea. All correlations were negative. Stepwise regression showed that only hematocrit was an independent correlate of the CRR (CRR = 0.662 - 007* Hct, R2 = 0.770); whereas, both hematocrit (Hct) and weight (W) were independent correlates of KT/V urea (KT/V = 2.070 - 0.005*Hct - 0.009*W,R2 = 0.721). In addition to creatinine clearance, urea clearance through the dialyzer is reduced by a rising hematocrit. The effect of hematocrit on urea clearance is relatively small. Therefore, it requires large changes in hematocrit in order to be detected.
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