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  • Title: Renal failure in a patient with chronic lymphocytic leukaemia treated with fludarabine.
    Author: Macheta MP, Parapia LA, Gouldesbrough DR.
    Journal: J Clin Pathol; 1995 Feb; 48(2):181-2. PubMed ID: 7745121.
    Abstract:
    The case history of a man with refractory chronic lymphocytic leukaemia who developed acute renal failure following treatment with fludarabine is presented. A renal biopsy specimen showed features of mesangiocapillary glomerulonephritis, a rare occurrence in chronic lymphocytic leukaemia. The rapid cytocidal action of fludarabine may result in the development of renal glomerular lesions when used to treat a well differentiated B cell malignancy.
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