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  • Title: [Clinical evaluation of a new oral penem, SY5555, in infants and children].
    Author: Kino M, Higashino H, Kobayashi Y.
    Journal: Jpn J Antibiot; 1995 Feb; 48(2):200-4. PubMed ID: 7745809.
    Abstract:
    A clinical study was performed on SY5555, a newly developed penem antibiotic, in children. SY5555 was given orally to 14 patients at 19-29 mg/kg/day in 3 doses for 4 to 12 days. Clinical evaluations were made on the 14 patients including 4 with pharyngitis, 7 with tonsillitis, one with urinary tract infection, and 2 with impetigo. Overall clinical effects were excellent in 2, good in 12, with an efficacy rate of 100%. Causative organisms (Staphylococcus aureus and Streptococcus pyogenes) were all eradicated. As to adverse reactions, mild diarrhea was observed in 4 patients. These data suggest that SY5555 is a useful oral antibiotic for the treatment of bacterial infections in children.
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