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  • Title: Augmentation of the immune response to influenza vaccine by acetylsalicylic acid: a clinical trial in a geriatric population.
    Author: Hsia J, Tang T, Parrott M, Rogalla K.
    Journal: Methods Find Exp Clin Pharmacol; 1994 Nov; 16(9):677-83. PubMed ID: 7746030.
    Abstract:
    The purpose of this placebo-controlled, double-blind, randomized trial was to evaluate the efficacy of oral acetylsalicylic acid (ASA), a comparatively safe, inexpensive biological response modifier, as an adjuvant to influenza vaccination in a geriatric population. 281 healthy adults, 65 years or older, received influenza vaccine and were randomized to ASA or placebo. Serum antibody against influenza A/Beijing and B/Panama, influenza antigen-stimulated blastogenesis and antigen-stimulated interleukin-2 production by peripheral blood mononuclear cells in vitro were increased following vaccination. Blastogenic response and interleukin-2 production increased to a similar extent in the two treatment groups. The proportion of participants with a 4-fold rise in specific antibody directed against influenza A/Beijing was greater among ASA recipients (p < 0.05). This difference was more marked in subjects > 75 years old (p < 0.01).
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