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Title: Measles outbreak in western Sydney. Vaccine failure or failure to vaccinate? Author: McDonnell LF, Jorm LR, Patel MS. Journal: Med J Aust; 1995 May 01; 162(9):471-5. PubMed ID: 7746203. Abstract: OBJECTIVES: To determine the effectiveness of measles vaccine during a measles outbreak, and to assess whether age at vaccination was a risk factor for measles vaccine failure. DESIGN: A matched case-control study. SETTING: The five primary schools in western Sydney with the largest number of measles cases during the June to December 1993 outbreak. SUBJECTS: Seventy-nine children aged 5-9 years with an illness consistent with a clinical definition for measles. Two controls per case were selected from children in the same classroom. MAIN OUTCOME MEASURES: Estimated measles vaccine effectiveness by age of the child at vaccination and vaccination status: "unvaccinated"; "parental recall" (parents stated the child was vaccinated but no record could be found); and "record" (record including date of vaccination available). RESULTS: The estimated vaccine effectiveness was 94% (95% confidence interval [CI], 83%-98%) in the "record" group, and 81% (95% CI, 46%-93%) in the "parental recall" group. Vaccine effectiveness did not differ significantly with age at vaccination (under 12 months of age 96% [64%-99%]; 12-14 months 95% [81%-99%]; and 15 months and over 93% [80%-98%]). CONCLUSION: Vaccination records should be used to calculate a vaccine's effectiveness as parental recall may not be sufficiently accurate. The high vaccine effectiveness in the "record" group (94%) makes it unlikely that low vaccine effectiveness was the cause of the outbreak. More effort is needed to increase vaccine coverage to at least 95% in all population subgroups.[Abstract] [Full Text] [Related] [New Search]