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  • Title: A comparison of nucleotide sequences of measles virus L genes derived from wild-type viruses and SSPE brain tissues.
    Author: Komase K, Rima BK, Pardowitz I, Kunz C, Billeter MA, ter Meulen V, Baczko K.
    Journal: Virology; 1995 Apr 20; 208(2):795-9. PubMed ID: 7747453.
    Abstract:
    The nucleotide sequences of the large protein (L) gene derived from two wild-type measles viruses (MV) and two SSPE brain-derived viruses have been determined. All sequences have single large open reading frames encoding 2183 amino acid residues. The deduced L proteins are well conserved and the proposed functional domains which have been identified for rhabdo- and paramyxoviruses are completely conserved in all strains. The degree of variability of L proteins is the lowest of all structural proteins of MV, reflecting its role in virus reproduction and persistence. Biased hypermutation was not observed in the L genes derived from SSPE brain tissue. None of the nucleotide changes can be associated with the attenuated phenotype of the Edmonston vaccine viruses.
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