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  • Title: The usefulness of calibration verification and linearity surveys in predicting acceptable performance in graded proficiency tests.
    Author: Lum G, Tholen DW, Floering DA.
    Journal: Arch Pathol Lab Med; 1995 May; 119(5):401-8. PubMed ID: 7748066.
    Abstract:
    OBJECTIVE: To assess the association between performance on graded chemistry surveys and evaluation of linearity and calibration in Linearity surveys. DESIGN: Data from Linearity Surveys (LN series) and from routine comprehensive College of American Pathologists chemistry surveys (all series) were used to evaluate the hypothesis that laboratories with nonlinear or univerified calibration would have a greater likelihood of unacceptable performance on comprehensive chemistry surveys. RESULTS: This study found that acceptable calibration verification evaluation is significantly related to acceptable rates for most analytes, including albumin, calcium, chloride, glucose, iron, magnesium, sodium, total bilirubin, uric acid, high-density lipoprotein cholesterol, triglycerides, alkaline phosphatase, alanine and aspartate aminotransferase, digoxin, gentamicin, phenobarbital, procainamide, and thyroxine. CONCLUSION: There is a consistent and strong relationship between calibration verification problems in the Linearity Surveys and failure rates in the College of American Pathologists chemistry surveys. Laboratories with poor calibration evaluations on Linearity Surveys have higher unacceptable rates on proficiency tests. Individual laboratories who were rated linear and whose calibration was verified by Linearity Surveys have lower unacceptable rates.
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