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  • Title: E-cadherin as a tumor (invasion) suppressor gene.
    Author: Birchmeier W.
    Journal: Bioessays; 1995 Feb; 17(2):97-9. PubMed ID: 7748170.
    Abstract:
    Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.
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