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  • Title: Somatogenic and lactogenic activity of the recombinant 22 kDa isoform of human placental growth hormone.
    Author: Igout A, Frankenne F, L'Hermite-Balériaux M, Martin A, Hennen G.
    Journal: Growth Regul; 1995 Mar; 5(1):60-5. PubMed ID: 7749349.
    Abstract:
    During pregnancy, the human placenta secretes a variant of pituitary growth hormone (hGH-V) differing in sequence from the pituitary growth hormone (hGH-N) by 13 amino acids substitutions. HGH-V replaces hGH-N in the maternal bloodstream during the second half of pregnancy. HGH-V is produced in two, possibly three, isoforms: a 22 kDa form, a glycosylated 25 kDa form, and a probable 26 kDa form resulting from alternative splicing of the mRNA. Here we have studied the somatogenic and lactogenic activity of recombinant 22 kDa hGH-V isoform produced in Escherichia coli and compared it with the 22 kDa form of hGH-N. The two variants exert a similar somatogenic effect on rabbit and rat cells, but differ as regards their lactogenic activity in the rat.
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