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  • Title: Passive immunization of insulin-like growth factor (IGF)-1 and of IGF-1 and IGF-2 in chickens.
    Author: Spencer GS, Decuypere E, Buyse J, Hodgkinson SC, Bass JJ, Zeman M.
    Journal: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol; 1995 Jan; 110(1):29-33. PubMed ID: 7749600.
    Abstract:
    The effects of passive immunization against IGF-1 either alone, or together with immunization against IGF-2, on growth and metabolism were examined in chickens. Immunization against IGF-1 alone had no effect upon any aspect of growth, carcass composition, efficiency of energy utilization or hormone concentrations studied. Immunization against both IGF-1 and IGF-2 together resulted in a lighter final body weight (P < 0.05) compared with controls. Immunization against both IGFs together decreased abdominal fat content (P < 0.05) and resulted in a heavier mean spleen weight (P < 0.01). The joint immunization was also associated with elevated plasma T3 concentrations. These data may indicate a role for IGF-2, but not for IGF-1, in fat metabolism in chickens.
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