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  • Title: Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
    Author: Doza YN, Cuenda A, Thomas GM, Cohen P, Nebreda AR.
    Journal: FEBS Lett; 1995 May 08; 364(2):223-8. PubMed ID: 7750576.
    Abstract:
    A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phosphorylation of both residues is required for the activation of this enzyme.
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