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  • Title: Urinary fibrin split products in lupus nephritis.
    Author: Zizic TM, Cwazka WF, Young NS, Stevens MB.
    Journal: J Rheumatol; 1976 Mar; 3(1):43-9. PubMed ID: 775087.
    Abstract:
    Antigen-antibody interaction and fibrin deposition at the glomerular basement membrane can release activators that ultimately convert fibrin into degradation products of varying molecular size. Thus, increased urinary fibrinogen/fibrin split products (FSP) might be expected in active lupus nephritis. A longitudinal study was done on 27 patients with biopsy-proven lupus nephritis. Those patients who were persistent FSP excretors were found to be at a significantly greater risk of progressive nephritis and renal death than those who were FSP negative. It is suggested that FSP excretion in lupus nephritis, particularly on a continued basis and despite normalization of other renal disease parameters, is a grave prognostic sign.
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