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  • Title: Structural investigations of the major allergen Phl p I on the complementary DNA and protein level.
    Author: Petersen A, Schramm G, Bufe A, Schlaak M, Becker WM.
    Journal: J Allergy Clin Immunol; 1995 May; 95(5 Pt 1):987-94. PubMed ID: 7751520.
    Abstract:
    Until now investigations of group I grass allergens have mainly been performed on ryegrass allergen (Lol p I). We studied this major allergen grass group with timothy grass pollen (Phl p I), a very common and important cause of type I allergy, to determine intraspecific and interspecific variations among different grass species. By immunoscreening a timothy grass pollen complementary DNA library we obtained three full-length clones. They revealed identical nucleotide sequences in the coding regions consisting of 262 amino acids, including a leader sequence of 23 amino acid residues. The comparison of our data with the amino acid sequences deduced from Lol p I and Hol 1 I clones showed sequence identities of greater than 85% and homologies of greater than 90%, indicating a high degree of sequence conservation. Despite the high degree of homology, amino acid differences were in immunodominant positions, which may be responsible for the differing immune response to group I allergens of different grass species.
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