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  • Title: On the similarity between the small Cl- channel and the taurine channel activated after cell swelling in Ehrlich ascites tumor cells.
    Author: Hoffmann EK, Lambert IH.
    Journal: Jpn J Physiol; 1994; 44 Suppl 2():S49-53. PubMed ID: 7752554.
    Abstract:
    The swelling-activated Cl- efflux, mediated by the mini Cl- channel (3-7 pS), and the swelling-activated taurine efflux in Ehrlich cells are both inhibited by the anion channel blocker MK196 (indacrinone). The swelling-activated taurine efflux is also inhibited by DIDS and following depolarization of the cell membrane, but it is significantly stimulated by arachidonic acid in the micromolar range. The swelling-activated Cl- efflux is, in contrast, only slightly affected by DIDS, unaffected by the membrane potential, and completely blocked by arachidonic acid in the micromolar range. It is suggested that the swelling-activated mini Cl- channel and the taurine channel in the Ehrlich cells represent two distinct types of channels.
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