These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of a lipid-lowering agent or a high-cholesterol diet on focal glomerulosclerosis in hyperlipidemic rats.
    Author: Yamasaki K, Yoshikawa Y.
    Journal: Lab Anim Sci; 1995 Feb; 45(1):54-8. PubMed ID: 7752615.
    Abstract:
    Hyperlipidemic rats given a diet supplemented with 1% probucol (4,4'-isopropylidenedithiobis [2,6-di-tert-butylphenol]) or 4% cholesterol with 1% cholic acid from 4 to 20 weeks of age were evaluated for the effect of a lipid-lowering agent or a high-cholesterol diet on focal glomerulosclerosis. Although mean cholesterol and phospholipid concentrations in hyperlipidemic rats given probucol were lower than those in control hyperlipidemic rats, there was no difference in urinary protein content or renal histologic findings when the two groups were compared. Mean cholesterol, phospholipid, urea nitrogen, and creatinine concentrations in hyperlipidemic rats given a high-cholesterol diet were greater than those in hyperlipidemic rats given a normal diet, and the glomerular sclerotic lesions became more severe.
    [Abstract] [Full Text] [Related] [New Search]