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  • Title: In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates.
    Author: Ang HH, Chan KL, Mak JW.
    Journal: Planta Med; 1995 Apr; 61(2):177-8. PubMed ID: 7753926.
    Abstract:
    Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta, 18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 microM, 0.389-3.498 microM, and 0.504-2.343 microM, respectively, compared with 0.323-0.774 microM for chloroquine.
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