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  • Title: Lipogenic activities in rat liver are subjected to circadian rhythms.
    Author: Zardoya R, Diez A, Serradilla MC, Madrid JA, Bautista JM, Garrido-Pertierra A.
    Journal: Rev Esp Fisiol; 1994 Dec; 50(4):239-44. PubMed ID: 7754166.
    Abstract:
    Diurnal variations were investigated in the activities of the key lipogenic enzymes in rat liver under standard experimental conditions. Fatty acid synthetase, acetyl-CoA-carboxylase, and ATP-citrate lyase showed sinusoidal circadian rhythms (statistically sustained), reaching maximum activity at night and minimum during the light period, with a fold increase value of 1.7, 2.2 and 3.2, respectively. Although a non-sinusoidal circadian rhythm was observed in the malic enzyme activity, statistically different time-dependent activity values were detected throughout a day. The observed rhythms run in parallel with that previously reported for glucose-6-phosphate dehydrogenase, suggesting a whole circadian regulation for rat liver lipogenesis.
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