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  • Title: [The nonuniform effect of anaprilin at different times of day on the dynamics of forced swimming in rats].
    Author: Arushanian EB, Beĭer EV.
    Journal: Eksp Klin Farmakol; 1994; 57(6):22-4. PubMed ID: 7756950.
    Abstract:
    The main parameters and rhythmicity of the forced swimming, including the rhythmical index of depression, had great daily variations. The beta-adrenoblocker anapriline changed the temporal dynamics of swimming and decreased the depression index. The peak effect was shown in the daytime after an acute administration of the drug. After chronic administration, the peak pharmacological activity changed during morning hours.
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