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  • Title: Inotropic effects of ouabain and Na, K-ATPase activity in failing rabbit hearts.
    Author: Ezzaher A, Mougenot R, Baggioni A, el Ouazzani T, Crozatier B, Maixent JM.
    Journal: C R Acad Sci III; 1995 Feb; 318(2):273-9. PubMed ID: 7757817.
    Abstract:
    Left ventricular (LV) function and Na+, K(+)-ATPase activity were studied in rabbit failing heart (FH) obtained by a double pressure plus volume overload which increased LV/body weight ratio by 58%. Ouabain (10(-6) M) increased peak dP/dt by 69% in control hearts (CH) but not in FH. Na+, K(+)-ATPase activity was similar in FH and in CH but the affinity of Na+, K(+)-ATPase for ouabain was significantly higher in CH than in FH (IC50: 2 microM vs 90 microM). The blunted LV contractile response to ouabain in FH is attributed to a decreased Na+, K(+)-ATPase affinity to ouabain and not to a decreased receptor density.
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