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  • Title: Suppression of nitric oxide toxicity in islet cells by alpha-tocopherol.
    Author: Burkart V, Gross-Eick A, Bellmann K, Radons J, Kolb H.
    Journal: FEBS Lett; 1995 May 15; 364(3):259-63. PubMed ID: 7758579.
    Abstract:
    We show here that preincubation of pancreatic islet cells with alpha-tocopherol significantly improves their resistance to toxic doses of nitric oxide (NO). No protection was afforded by other antioxidants such as vitamin C or glutathione-monoethyl ester. The pathway of NO induced islet cell death involves DNA damage and excessive activation of poly(ADP-ribose)polymerase leading to irreversible depletion of intracellular NAD+. alpha-Tocopherol was found to interfere at early steps of this pathway, by preventing the occurrence of DNA strand breaks. This indicates that alpha-tocopherol directly interacts with NO or its reactive intermediates. We conclude that alpha-tocopherol is not only part of the cellular defence system against oxygen radicals but also protects eukaryotic cells from NO toxicity.
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