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  • Title: [Reaction of the lysosomal apparatus of neutrophilic leukocytes in the peripheral blood and immunoreactivity of the organism during immobilization].
    Author: Lunina NV, Dobrovolśka VE.
    Journal: Fiziol Zh (1994); 1994; 40(2):68-73. PubMed ID: 7758608.
    Abstract:
    Experiments carried out on mature rabbits have shown that 12-hours-long immobilization induced in the peripheral blood of animals neutrophilic leukocytosis accompanied by a decrease in the amount of lysosomas and granules of lysosomal cationic proteins in neutrophilocytes. In compliance with this the activity of acid phosphatase (AP), a marker lysosomal enzyme of granulocytes, in the blood serum has grown. Under these conditions we observed guantitative changes in humoral (an increase in the amount of circulating immune complexes (CIC) in the lymph as well as in B-cells) and in cellular (general T-lymphopenia, a sharp increase in the number of T-theophylline-sensitive and T-theophylline-resistant lymphocytes) components of the immunity at the initial period of the stress-syndrome formation. It is supposed that there is a definite relation between immunoreactivity of the organism and activity of lysosomal enzymes of neutrophilic granulocytes in the peripheral blood under conditions of immobilization stress.
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