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  • Title: [Study of the growth patterns of Act. antibioticus and the biosynthesis of oleandomycin].
    Author: Surikova EI, Novikova LM, Gerasimova TM.
    Journal: Antibiotiki; 1976 Mar; 21(3):195-200. PubMed ID: 776074.
    Abstract:
    The study of some regularities of the oleandomycin-producing organism growth during the first stage of cultivation showed that an increase in the ammount of starch in the medium from 2 to 10 per cent promoted the growth and its specific rate. When the organism was cultivated on media with 2--6 per cent of starch, addition of ammonium sulfate in a concentration of 0.25--0.5 per cent was favourable for its growth. When the amount of starch was 8--10 per cent, ammonium sulfate in a concentration of 0.25--1.5 per cent had almost no effect on the growth and its specific rate. It was found that an increase in the amount of starch in the medium without ammonium sulfate promoted the mycelium growth and oleandomycin biosynthesis by 20 per cent, the time of cultivation being prolongated. Ammonium sulfate significantly stimulated the mycelium growth and decreased biosynthesis of oleandomycin. Additional introduction of starch solution in a concentration of 1 or 2 per cent during the first hours of the culture growth (24 hours) on the medium with 2 per cent of starch stimulated the growth, its specific rate and biosynthesis of oleandomycin by 20--30 per cent and the cultivation time increased. Simulataneous addition of starch and ammonium sulfate to the culture during the first hours of the growth (24 hours) decreased the biosynthesis of oleandomycin. The maximum respiration rate of the culture in flasks was registered in 24 hours, then it was followed by a decrease. Addition of starch and ammonium sulfate during the cultivation process, i.e. in 24, 48 and 72 hours increased every time the rate of the organism respiration.
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