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  • Title: Variability of beta-amyloid protein deposited lesions in Down's syndrome brains.
    Author: Ikeda S, Tokuda T, Yanagisawa N, Kametani F, Ohshima T, Allsop D.
    Journal: Tohoku J Exp Med; 1994 Nov; 174(3):189-98. PubMed ID: 7761984.
    Abstract:
    An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.
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